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InvestigationalNot a peptideMetabolic / GLP-1

CagriSema

Black-and-white illustration for CagriSema

ALSO SOLD AS Cagrilintide + semaglutide

See the stack breakdown →

Last reviewed 2026-10-30

Our read Opinion

REDEFINE 1 provides phase 3 randomized evidence of weight reduction. The investigational cagrilintide component makes the combination prohibited under WADA S0.

01—At a glance
Type
Investigational (in trials)
Regulatory status
Investigational combination; not FDA-approved
Compounding status
Not allowed (blends excluded)
FDA-approved indications
None
Evidence level
Human trials ongoing
Routes studied
—
WADA
Prohibited
Developer
Novo Nordisk
02—What it's claimed to do

Claims made by researchers, companies and users. Inclusion does not mean the claim is verified.

  • —Claimed to produce more weight loss than semaglutide alone
03—How it's thought to work

Combines amylin-receptor agonism from cagrilintide with GLP-1 receptor agonism from semaglutide to reduce appetite and food intake.

04—Regulatory status

Not a peptide: a pre-mixed blend of cagrilintide and semaglutide, developed by Novo Nordisk as an investigational combination product. Semaglutide approval does not confer approval on CagriSema; no combination marketing authorization was verified.

Statuses change; check the linked primary source.

05—Evidence vs. Hype

Momentum Opinion

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0 news items in last 30 days

06—Our Take (opinion)

Phase 3 evidence makes this more than a speculative stack, but it remains a distinct investigational product. Unregulated mixtures should not borrow the credibility of sponsor-controlled trials.

07—Latest news

No news yet for this peptide.

08—Sources

Information only. Not medical advice. Listing a compound is not an endorsement or a recommendation to obtain or use it. Ratings and "Our Take" are editorial opinion. Full disclaimer.